Lupron Depot-PED® for Central Precocious Puberty

About Lupron Depot-PED

Lupron Depot-PED is a synthetic analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH) indicated for the treatment of children with central precocious puberty (CPP).

In this section of the site, learn about Lupron Depot-PED:

Efficacy. Lupron Depot-PED reduces pituitary gonadotropins to prepubertal levels. This effect is reversible upon discontinuation.
Dosing. How to dose and administer Lupron Depot-PED.
Safety. Read important safety information about Lupron Depot-PED.

Selection Criteria¹

Children should be selected for therapy with Lupron Depot-PED using the following criteria:

Clinical diagnosis of CPP (idiopathic or neurogenic) with onset of secondary sexual characteristics earlier than 8 years in females and 9 years in males.
Confirmation of diagnosis prior to initiation of therapy:
- Confirmation of diagnosis by a pubertal response to a GnRH stimulation test. The sensitivity and methodology of this assay must be understood.
- Bone age advanced one year beyond the chronological age.
Baseline evaluation should also include:
- Height and weight measurements.
- Sex steroid levels.
- Adrenal steroid level to exclude congenital adrenal hyperplasia.
- Beta human chorionic gonadotropin level to rule out a chorionic gonadotropin secreting tumor.
- Pelvic/adrenal/testicular ultrasound to rule out a steroid secreting tumor.
- Computerized tomography of the head to rule out intracranial tumor.

Learn about Lupron Depot-PED efficacy

Important Safety and Other Information

In clinical studies, the most frequent adverse event related to therapy with Lupron Depot-PED was an injection site reaction, seen in 5% of children in the combined studies. The recommended starting dose of Lupron Depot-PED is 0.3 mg/kg/4 weeks (minimum 7.5 mg). Inadequate dosing may result in poor control of the pubertal process, allowing continued sexual development; therefore, adherence to the 4-week dosing interval must be maintained. Stimulation of sexual development may occur after the first dose or if the dose is inadequate. Lupron Depot-PED is indicated in the treatment of children with central precocious puberty. Individual results may vary. Please see the full Prescribing Information and the Patient Product Information.

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All photos are of models and not of users of Lupron Depot-PED or persons suffering symptoms described.


Central Precocious Puberty Main Diagnosis About Lupron Depot PED Efficacy Dosing & Administration Safety Information Resources for Your Patients Links Procurement Questionnaire Links	About Lupron Depot-PED Lupron Depot-PED is a synthetic analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH) indicated for the treatment of children with central precocious puberty (CPP). In this section of the site, learn about Lupron Depot-PED: Efficacy. Lupron Depot-PED reduces pituitary gonadotropins to prepubertal levels. This effect is reversible upon discontinuation. Dosing. How to dose and administer Lupron Depot-PED. Safety. Read important safety information about Lupron Depot-PED. Selection Criteria¹ Children should be selected for therapy with Lupron Depot-PED using the following criteria: Clinical diagnosis of CPP (idiopathic or neurogenic) with onset of secondary sexual characteristics earlier than 8 years in females and 9 years in males. Confirmation of diagnosis prior to initiation of therapy: Confirmation of diagnosis by a pubertal response to a GnRH stimulation test. The sensitivity and methodology of this assay must be understood. Bone age advanced one year beyond the chronological age. Baseline evaluation should also include: Height and weight measurements. Sex steroid levels. Adrenal steroid level to exclude congenital adrenal hyperplasia. Beta human chorionic gonadotropin level to rule out a chorionic gonadotropin secreting tumor. Pelvic/adrenal/testicular ultrasound to rule out a steroid secreting tumor. Computerized tomography of the head to rule out intracranial tumor. Learn about Lupron Depot-PED efficacy	Now you can order Lupron Depot online. Once you've set up an account, it only takes a few clicks. Find out how to dose Lupron Depot-PED based on the child's weight.

About Lupron Depot-PED

In this section of the site, learn about Lupron Depot-PED:

Selection Criteria1

Important Safety and Other Information

References

Selection Criteria¹