Lupron Depot-PED® for Central Precocious Puberty: Efficacy

Efficacy of Lupron Depot-PED in Central Precocious Puberty

In children with central precocious puberty (CPP), stimulated and basal gonadotropins (testosterone in males and estradiol in females) are reduced to prepubertal levels.¹ Reduction of gonadotropin levels allows for normal physical and psychological growth and development.¹ Natural maturation occurs when gonadotropins return to pubertal levels following discontinuation of Lupron Depot-PED.¹

Chronic administration of Lupron Depot-PED in children with CPP can help:¹

Promote skeletal growth. A measurable increase in body length can be noted since the epiphyseal plates will not close prematurely.

Reverse reproductive organ growth. Reproductive organs will return to a prepubertal state.

Stop menses. Menses, if present, will cease.

In a study of 22 children with CPP who received Lupron Depot-PED every 4 weeks dosed according to weight categories, mean trough plasma leuprolide levels ≥ 0.77 ng/mL were recorded in all weight groups at week 4 immediately prior to injection.

Discontinuation of Lupron Depot-PED should be considered before age 11 for females and age 12 for males.

Important Safety and Other Information

In clinical studies, the most frequent adverse event related to therapy with Lupron Depot-PED was an injection site reaction, seen in 5% of children in the combined studies. The recommended starting dose of Lupron Depot-PED is 0.3 mg/kg/4 weeks (minimum 7.5 mg). Inadequate dosing may result in poor control of the pubertal process, allowing continued sexual development; therefore, adherence to the 4-week dosing interval must be maintained. Stimulation of sexual development may occur after the first dose or if the dose is inadequate. Lupron Depot-PED is indicated in the treatment of children with central precocious puberty. Individual results may vary. Please see the full Prescribing Information and the Patient Product Information.

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All photos are of models and not of users of Lupron Depot-PED or persons suffering symptoms described.

References

Lupron Depot-PED Full Prescribing Information.


Central Precocious Puberty Main Diagnosis About Lupron Depot PED Efficacy Dosing & Administration Safety Information Resources for Your Patients Links Procurement Questionnaire Links	Efficacy of Lupron Depot-PED in Central Precocious Puberty In children with central precocious puberty (CPP), stimulated and basal gonadotropins (testosterone in males and estradiol in females) are reduced to prepubertal levels.¹ Reduction of gonadotropin levels allows for normal physical and psychological growth and development.¹ Natural maturation occurs when gonadotropins return to pubertal levels following discontinuation of Lupron Depot-PED.¹ Chronic administration of Lupron Depot-PED in children with CPP can help:¹ Promote skeletal growth. A measurable increase in body length can be noted since the epiphyseal plates will not close prematurely. Reverse reproductive organ growth. Reproductive organs will return to a prepubertal state. Stop menses. Menses, if present, will cease. In a study of 22 children with CPP who received Lupron Depot-PED every 4 weeks dosed according to weight categories, mean trough plasma leuprolide levels ≥ 0.77 ng/mL were recorded in all weight groups at week 4 immediately prior to injection. Discontinuation of Lupron Depot-PED should be considered before age 11 for females and age 12 for males. Learn more about dosing Lupron Depot-PED	Now you can order Lupron Depot online. Once you've set up an account, it only takes a few clicks. Find out how to dose Lupron Depot-PED based on the child's weight.