Lupron Depot® for Endometriosis: Efficacy Info from TAP

Important Safety and Other Information

Side effects are generally those related to hypoestrogenism, including vasomotor flushes, headaches, and vaginal dryness. After 6 months of therapy with Lupron Depot 3.75 mg, vertebral bone density decreased by an average of 3.2% compared with the pretreatment value. Lupron Depot is indicated for the management of endometriosis, including pain relief and reduction of endometriotic lesions. Individual results may vary. Please see the full Prescribing Information for Lupron Depot 3.75 mg and -3 Month 11.25 mg dosage forms, and the Patient Product Information for the 3.75 mg and -3 Month 11.25 mg dosage forms.

The most commonly reported side effects of Lupron Depot plus norethindrone acetate 5 mg daily are vasomotor flushes, headache, nausea/vomiting, depression/emotional lability, and asthenia. In addition, Lupron Depot plus norethindrone acetate-treated patients had significantly decreased HDL levels and significantly increased LDL/HDL ratios. After treatment, mean serum lipid levels in patients with follow-up data returned to pretreatment values. Norethindrone acetate should be used with caution in women with cardiovascular risk factors including lipid abnormalities and cigarette smoking. Please refer to the norethindrone acetate prescribing information for warnings, precautions, contraindications and adverse reactions. Lupron Depot is indicated for the management of endometriosis, including pain relief and reduction of endometriotic lesions. Lupron Depot with norethindrone acetate 5 mg daily is also indicated for initial management of endometriosis and for management of recurrence of symptoms. Duration of initial treatment or retreatment should be limited to 6 months. Individual results may vary. Please see the full Prescribing Information for Lupron Depot 3.75 mg and -3 Month 11.25 mg dosage forms, and the Patient Product Information for the 3.75 mg and -3 Month 11.25 mg dosage forms.

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References

Ling FW. Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis. Pelvic Pain Study Group. Obstet Gynecol. 1999;93(1):51-58.
Winkel CA, Bray M. Use of leuprolide acetate in combination with surgical treatment for women with endometriosis. In: Minaguchi H and Sugimoto O, eds. Endometriosis Today, Advances in Research and Practice: The Proceedings of the Vth World Congress on Endometriosis, Yokohama, Japan, October 1996. New York, NY: Parthenon Publishing Group; 1997:365-369.
Lupron Depot -3 Month 11.25 mg Full Prescribing Information.
Dlugi AM, Miller JD, Knittle J. Lupron Study Group. Lupron Depot in the treatment of endometriosis: a randomized, placebo-controlled, double-blind study. Fertil Steril. 1990;54(3):419-427.
ACOG Practice Bulletin. Medical management of endometriosis. Number 11, December 1999 (replaces Technical Bulletin Number 184, September 1993). Clinical management guidelines for obstetrician-gynecologists. Int J Gynaecol Obstet. 2000;71(2):183-196.

Efficacy of Lupron Depot in Endometriosis

Percent of Patients Reporting Decrease in Symptoms (N = 88)¹

Lasting Relief

Percent of Patients Pain-Free at 12 and 24 Months After Treatment (N = 240)

Important Safety and Other Information

References


Endometriosis Main Hormone Therapy About Lupron Depot Efficacy Add-Back Therapy Dosing & Administration Safety Information Resources for Your Patients Links Procurement Physician Materials Links	Efficacy of Lupron Depot in Endometriosis Lupron Depot can deliver powerful, proven relief from the pain of endometriosis.^1,4 In one study of women with clinically suspected endometriosis, 12 weeks of Lupron Depot therapy relieved the symptoms of endometriosis in 80% or more of patients, as demonstrated below.¹ Percent of Patients Reporting Decrease in Symptoms (N = 88)¹ Post-treatment laparoscopy pathologically confirmed endometriosis in 82% of patients with clinically suspected disease. Lasting Relief Lupron Depot can offer lasting pain relief. One year after a full 6-month course of Lupron Depot:³ 76% of women with dyspareunia were symptom-free (n = 25) 61% of women with pelvic tenderness were symptom-free (n = 28) 53% of women with pelvic pain were symptom-free (n = 30) 23% of women with dysmenorrhea were symptom-free (n = 30) Lupron Depot can also help provide long-lasting relief from endometriosis pain.^2,5 Percent of Patients Pain-Free at 12 and 24 Months After Treatment (N = 240) Study of 240 women with endometriosis and pelvic pain who underwent surgical treatment with or without adjunctive medical therapy for 6 months. Adapted with permission from Winkel and Bray, 1996.² Learn about dosing Lupron Depot	Now you can order Lupron Depot online. Once you've set up an account, it only takes a few clicks. Add-back therapy with an exogenous progestin can reduce some side effects of GnRH agonists, without sacrificing efficacy.

Efficacy of Lupron Depot in Endometriosis

Percent of Patients Reporting Decrease in Symptoms (N = 88)1

Lasting Relief

Percent of Patients Pain-Free at 12 and 24 Months After Treatment (N = 240)

Important Safety and Other Information

References

Percent of Patients Reporting Decrease in Symptoms (N = 88)¹