Lupron Depot® for Uterine Fibroids: Efficacy Info from TAP

Efficacy of Lupron Depot in Uterine Fibroids

For women with anemia due to uterine fibroids, Lupron Depot in combination with iron provides improvement in hematocrit and hemoglobin counts.¹

Percent of Patients Achieving Hematocrit ≥36% and Hemoglobin ≥12g/dL

Lupron Depot® for Anemia from Uterine Fibroids: Hemocrit and Hemoglobin

* p<0.01
** p<0.001

In a study of women with hematocrit ≤30% and/or hemoglobin ≤10.2 g/dL, 75% of women who received Lupron Depot 3.75 mg concomitantly with iron achieved clinical response at three months.¹ These patients demonstrated a hematocrit increase ≥6% and hemoglobin increase ≥2 g/dL.¹

Lupron Depot 3.75 mg was also found to relieve symptoms of bloating, pelvic pain, and pressure.¹ Clinical studies have shown a decrease in uterine and myoma volume, 41% and 37% respectively.¹ Menorrhagia or menometrorrhagia was relieved in 80% of patients.¹

Reversible Amenorrhea

In studies of women in which enrollment was not based on hematological status, 95% of these patients became amenorrheic, with 61%, 25%, and 4% experiencing amenorrhea during the first, second, and third treatment months respectively.¹ This effect is reversible upon discontinuation of Lupron Depot.¹

Learn about dosing Lupron Depot

Important Safety and Other Information

Side effects are generally those related to hypoestrogenism, including vasomotor flushes, headaches, and vaginal dryness. After 3 months of therapy of Lupron Depot 3.75 mg, vertebral bone density decreased by an average 2.7% compared with the pretreatment value. Use beyond 3 months is not recommended. Lupron Depot concomitantly with iron therapy is indicated for the preoperative hematologic improvement of patients with anemia caused by uterine leiomyomata (fibroids). Individual results may vary. Please see the full Prescribing Information for Lupron Depot 3.75 mg and -3 Month 11.25 mg dosage forms, and the Patient Product Information for the 3.75 mg and -3 Month 11.25 mg dosage forms.

You will need Adobe® Reader® to view and print the prescribing information and patient product information. To download the free reader, click on the icon below.


Uterine Fibroids Main About Lupron Depot Efficacy Dosing & Administration Safety Information Resources for Your Patients Links Procurement Physician Materials Links	Efficacy of Lupron Depot in Uterine Fibroids For women with anemia due to uterine fibroids, Lupron Depot in combination with iron provides improvement in hematocrit and hemoglobin counts.¹ Percent of Patients Achieving Hematocrit ≥36% and Hemoglobin ≥12g/dL * p<0.01 ** p<0.001 In a study of women with hematocrit ≤30% and/or hemoglobin ≤10.2 g/dL, 75% of women who received Lupron Depot 3.75 mg concomitantly with iron achieved clinical response at three months.¹ These patients demonstrated a hematocrit increase ≥6% and hemoglobin increase ≥2 g/dL.¹ Lupron Depot 3.75 mg was also found to relieve symptoms of bloating, pelvic pain, and pressure.¹ Clinical studies have shown a decrease in uterine and myoma volume, 41% and 37% respectively.¹ Menorrhagia or menometrorrhagia was relieved in 80% of patients.¹ Reversible Amenorrhea In studies of women in which enrollment was not based on hematological status, 95% of these patients became amenorrheic, with 61%, 25%, and 4% experiencing amenorrhea during the first, second, and third treatment months respectively.¹ This effect is reversible upon discontinuation of Lupron Depot.¹ Learn about dosing Lupron Depot	Now you can order Lupron Depot online. Once you've set up an account, it only takes a few clicks. Pharmacy Solutions, a licensed pharmacy, can help your office streamline reimbursement and delivery of Lupron Depot. To enroll, call: 1-800-859-0220

Efficacy of Lupron Depot in Uterine Fibroids

Percent of Patients Achieving Hematocrit ≥36% and Hemoglobin ≥12g/dL

Reversible Amenorrhea

Important Safety and Other Information

Reference