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Side effects are generally those related to hypoestrogenism, including vasomotor flushes, headaches, and vaginal dryness. After 3 months of therapy of Lupron Depot 3.75 mg, vertebral bone density decreased by an average 2.7% compared with the pretreatment value. Use beyond 3 months is not recommended. Lupron Depot concomitantly with iron therapy is indicated for the preoperative hematologic improvement of patients with anemia caused by uterine leiomyomata (fibroids). Individual results may vary. Please see the full Prescribing Information for Lupron Depot 3.75 mg and -3 Month 11.25 mg dosage forms, and the Patient Product Information for the 3.75 mg and -3 Month 11.25 mg dosage forms.
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